Drugs & Vitamins

Active Ingredients: Urokinase
Drug Class: Thrombolytic Agents
Rx Status: Available by prescription only
Generic Available: No
Product Images & Descriptions:

What is/are Urokinase? (Back to top)
UROKINASE breaks-up blood clots. It is used to treat large blood clots formed in the lungs. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• aneurysm
• bleeding problems or problems with blood clotting
• blood vessel disease or damaged blood vessels
• diabetic retinopathy
• head injury or tumor
• high blood pressure
• infection
• irregular heartbeats
• recent biopsy or surgery
• an unusual or allergic reaction to urokinase, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
This does not apply.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• aminocaproic acid
• aprotinin
• tranexamic acid

• antiinflammatory drugs, NSAIDs like ibuprofen
• aspirin and aspirin-like medicines
• dipyridamole
• drotrecogin alfa
• fish oil (omega-3 fatty acids) supplements
• ginkgo
• medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• blue color to lips or nailbeds
• breathing problems
• changes in vision
• chest pain or tightness
• dark urine, stools, or vomit
• fast, irregular heartbeat
• fever, chills
• nausea, vomiting
• trouble passing urine or change in the amount of urine
• unusual bleeding, bruising, or purple spots on the skin

• feeling faint or lightheaded

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I watch for while using this medicine? (Back to top)
Your condition will be monitored carefully while you are receiving this medicine.

This medicine contains albumin from human blood. It may be possible to pass an infection in this medicine. Talk to your doctor about the risks and benefits of this medicine.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Do not take aspirin, ibuprofen, or other nonprescription pain relievers for several days after receiving this medicine.

Where should I keep this medicine? (Back to top)
This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:February 26, 2008

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